How it works:
Calcium folinate (leucovorin) is an active form of folic acid that does not require metabolic activation. In oncology, it is used for “leucovorin rescue” therapy to protect normal cells from the toxic effects of high-dose methotrexate. It also enhances the antitumor activity of fluorouracil by stabilizing the binding to thymidylate synthase, increasing cytotoxicity against malignant cells.
Who it is recommended for:
Clinical studies and evidence:
Calcium folinate is widely included in international oncology treatment protocols, particularly for colorectal cancer. Numerous clinical trials have demonstrated its effectiveness in reducing hematologic and gastrointestinal toxicity associated with methotrexate. In combination with 5-fluorouracil, it has been shown to improve overall survival and response rates in colorectal cancer patients. The drug is recognized in established clinical guidelines and oncology standards of care.
Indicated for reducing the toxicity and counteracting the effects of folic acid antagonists such as methotrexate. It is also used as part of combination therapy for malignant neoplasms. The drug enhances fluorouracil efficacy and protects normal tissues during chemotherapy.
Dosage and treatment regimen are determined individually based on the chemotherapy protocol and patient condition. The medication is taken orally strictly according to physician instructions. Duration and frequency are carefully monitored by a healthcare professional.
Contraindications
Side effects
