ACNETOP 10tubes of 20g (Clindamycin Phosphate, Nicotinamide)

How it works

• Clindamycin is a lincosamide antibiotic. Following topical application, clindamycin phosphate is converted to active clindamycin.
• Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. 
• Nicotinamide, also known as niacinamide, has anti-inflammatory properties and is used in topical acne therapy.
• The combination is intended primarily to address inflammatory acne lesions.

Who may benefit

• People with inflammatory acne vulgaris.
• Patients for whom a healthcare professional has prescribed topical antibacterial treatment for acne.
• Individuals with acne-prone skin when used according to professional advice and the product instructions.

Research and clinical evidence

Topical clindamycin has been extensively studied for acne vulgaris and is used in topical medicinal formulations for the treatment of acne. 

A double-blind clinical study involving 76 patients compared 4% topical nicotinamide with 1% clindamycin gel in moderate inflammatory acne. After 8 weeks, both treatments produced clinical improvement and reductions in inflammatory lesions, with no statistically significant difference between the groups in the principal efficacy measures. 

Another clinical study similarly found significant improvement in acne severity with both topical nicotinamide and clindamycin over 4 and 8 weeks, without a significant difference between treatments in the primary outcomes. 

A recent systematic review and meta-analysis of randomized controlled trials supports the efficacy of several topical clindamycin-containing regimens for mild-to-moderate acne, particularly in combination therapies. However, prolonged use of topical antibiotics should be approached cautiously because of the potential development of antimicrobial resistance.