Adapalene is a topical retinoid that acts on processes involved in the development of acne lesions. It normalizes keratinocyte differentiation and reduces abnormal accumulation of skin cells that can contribute to pore blockage. Adapalene also has anti-inflammatory activity, helping reduce inflammatory acne lesions.
The efficacy and safety of adapalene have been evaluated in controlled clinical studies for the treatment of acne. Original adapalene 0.1% formulations have been studied in multicenter clinical trials assessing changes in inflammatory and non-inflammatory acne lesions.
For Differin Lotion 0.1%, which contains the same active ingredient, registration studies included two 12-week, multicenter, controlled clinical trials involving a total of 2,141 acne patients. These studies evaluated efficacy and safety compared with the vehicle without active drug.
Galderma describes adapalene 0.1% as a topical retinoid that acts within the pilosebaceous units to normalize abnormal accumulation of skin cells that can block pores and to decrease local inflammation.
Approved indications, age restrictions, and prescription status may vary between countries. The locally approved product information should therefore be followed for ADAFERIN.
ADAFERIN containing adapalene 0.1% is used for the topical treatment of mild to moderate acne vulgaris, particularly when comedones, papules, and pustules are present.
The primary purpose of treatment is to reduce the formation of new acne lesions and improve the overall condition of acne-prone skin with regular use.
Adapalene acts on keratinization processes within the pilosebaceous follicles, helping prevent comedone formation and providing an anti-inflammatory effect.
Apply a thin layer of the gel to clean, dry skin in the affected areas, generally once daily, preferably in the evening. Avoid contact with the eyes, lips, mucous membranes, and damaged or irritated skin. Applying excessive amounts does not increase effectiveness and may increase skin irritation. The duration of treatment should be determined according to acne severity and the recommendations of a healthcare professional.
