How it works:
Tenofovir Alafenamide is a prodrug that activates within infected cells, inhibiting reverse transcriptase enzymes essential for HBV and HIV replication. It is effective at low doses, reducing systemic exposure and limiting renal and bone toxicity compared to earlier tenofovir formulations.
Recommended for:
Patients with chronic hepatitis B
Individuals undergoing antiretroviral therapy for HIV
Those requiring reduced toxicity antiviral options
Used in combination regimens for HIV-1 and HBV infection
Treatment of chronic hepatitis B in adults
Part of combination antiretroviral therapy for HIV-1 infection
Administer orally once daily with food. The duration and combination of therapy should be determined by a healthcare professional based on clinical assessment.
Hypersensitivity to tenofovir or any excipients
Severe renal impairment
Severe hepatic impairment
Use in children without medical indication
Nausea, headache
Elevated liver enzymes
Decreased bone mineral density
Elevated serum creatinine
Fatigue and muscle weakness
