Mechanism of Action:
- High-affinity agonist of KISS1R receptors in arcuate nucleus of hypothalamus
- Induces pulsatile secretion of gonadotropin-releasing hormone
- Stimulates release of luteinizing and follicle-stimulating hormones
- Activates cascade of sex steroid synthesis in gonads
Recommended for:
- Patients with severe forms of hypogonadotropic hypogonadism
- Couples with idiopathic infertility of unknown origin
- Women with polycystic ovary syndrome (PCOS)
- Men with oligoasthenospermia and endocrine infertility
- Preparation for assisted reproductive technologies
Research and Studies:
Multicenter clinical studies confirm:
- 600-800% increase in LH levels 30-45 minutes after injection
- Restoration of ovulation in 85% of women with endocrine infertility
- Improvement of spermogram parameters in 75% of men with oligospermia
- Normalization of menstrual cycle in 90% of patients with amenorrhea
- Successful use in IVF programs for ovulation synchronization
- Severe forms of hypogonadotropic hypogonadism
- Idiopathic infertility in men and women
- Polycystic ovary syndrome with anovulation
- Preparation for assisted reproduction procedures
- Disorders of pulsatile gonadotropin secretion
The drug is dissolved in 1-2 ml of sterile water for injections and administered subcutaneously in the abdominal area. Recommended dosage is 200-400 mcg 1-2 times daily. Treatment course duration is determined individually and usually lasts 2-4 months under sex hormone level control.
Contraindications:
- Hormone-sensitive malignant tumors of reproductive system
- Pregnancy and breastfeeding
- Severe hepatic and renal insufficiency
- Undiagnosed pituitary masses
- Acute inflammatory diseases of pelvic organs
Side Effects:
- Local hyperemia and pain at injection site
- Transient nausea and dizziness
- Emotional lability and irritability
- Breast tenderness and engorgement
- Allergic reactions in case of individual intolerance
