Mechanism of Action:
Inhibits angiogenesis and tumor cell proliferation
Enhances immune response against malignant cells
Reduces pro-inflammatory cytokine production
Recommended for:
Multiple Myeloma patients (in combination with dexamethasone)
5q-associated Myelodysplastic Syndrome (MDS)
Multiple Myeloma (second-line and subsequent therapy)
5q-deletion Myelodysplastic Syndrome
Maintenance therapy post stem cell transplantation
Standard dose: 25 mg/day in 28-day cycles
Take once daily with water
Best time: evening, 1-2 hours after meal
Contraindications:
Pregnancy (Category X)
Severe hepatic impairment
Hypersensitivity
Side Effects:
Neutropenia, thrombocytopenia
Deep vein thrombosis
Fatigue, skin rash
