MACPEE is a direct-acting cholinergic agonist that stimulates muscarinic receptors in smooth muscle tissue.
How it works:
Bethanechol chloride activates muscarinic receptors of the parasympathetic nervous system, increasing detrusor muscle tone and promoting effective bladder emptying. The medication has minimal activity on nicotinic receptors, reducing the risk of systemic adverse effects.
Recommended for:
Clinical evidence:
Bethanechol chloride has been used in medical practice for decades. Clinical studies demonstrate improved bladder contractility following surgery and in patients with neurogenic bladder disorders. Data show significant improvement in urodynamic parameters and reduction in post-void residual urine volume under medical supervision.
Indicated for functional urinary retention, bladder atony, and neurogenic bladder dysfunction. It works by stimulating muscarinic receptors, enhancing smooth muscle contraction and facilitating urination.
Take orally as prescribed by a healthcare provider. Dosage and duration of treatment are determined individually based on clinical response. It is generally recommended to take the medication on an empty stomach unless otherwise directed.
Contraindications
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