Quatrefolic®: A Bioactive Folate Revolution for Health and Pregnancy

What is Quatrefolic®?

Quatrefolic® is the fourth-generation folate — a bioactive form of folic acid known as (6S)-5-methyltetrahydrofolate glucosamine salt. Unlike regular folic acid, which must undergo multiple metabolic steps in the liver, Quatrefolic® is immediately usable by the human body. It bypasses the MTHFR (methylenetetrahydrofolate reductase) enzyme, making it a critical innovation for people with MTHFR polymorphism (up to 40% of the population).

Clinical Advantages of Quatrefolic®

• ✅ Directly bioavailable: No conversion needed, unlike folic acid
  
  
• ✅ Safe for individuals with MTHFR mutation
  
  
• ✅ Improves homocysteine regulation — linked to cardiovascular protection
  
  
• ✅ Enhances pregnancy outcomes
  
  
• ✅ Supports brain function and DNA synthesis
  
  

Women's Health & Fertility

Quatrefolic® is increasingly included in prenatal supplements due to its higher bioefficacy. A 2021 study published in Reproductive Toxicology showed improved embryo quality and lower miscarriage rates in women taking Quatrefolic® vs traditional folic acid.

Studies Confirm:

• 60% better red blood cell folate increase
  
  
• Enhanced folate delivery to neural tissues in fetuses
  
  
• Reduced neural tube defect risk even in high-risk women
  
  

Neurological and Cognitive Health

In elderly patients, Quatrefolic® has been associated with better memory retention, reduction in mild cognitive impairment (MCI) symptoms, and lower homocysteine levels, which are neurotoxic in excess.

Clean-Label & Vegan

Quatrefolic® is:

• Non-GMO
  
  
• Allergen-free
  
  
• Halal & Kosher
  
  
• Vegan-certified

It is ideal for use in premium nutraceuticals like Cherish Life by Sacred Leaves — a women's formula designed to optimize hormonal balance, energy, and mood.

Scientific Sources:

• NIH (PubMed ID: 33080274)
  
  
• EFSA Scientific Opinion 2013
  
  
• Reprod Toxicol. 2021; 104:34–42
  
  
• Gnosis by Lesaffre Technical Data Sheets